Figure 6

Multifunctional capabilities of the CSNAs (Fe(salen)-loaded CSNAs). (a) Magnetic resonance images of the bovine serum albumin (BSA)- or gum arabic (GA)-coated CSNAs. A sample of each low concentration (0–4.41 mM) was acquired with a 7-Tesla scanner for T2W and mapping. (b) The proton longitudinal relaxation rate (R1) and transverse relaxation rate (R2) of the bio-functionalized CSNA samples were calculated quantitatively to confirm linearity in contrast to Fe(salen). (c) AMF-induced heat generation profiles of the CSNA products in powder (the top) and saline solution (the bottom), and the in vitro fluorescent cytotoxicity assay (in vivo imaging system) using the BSA-CSNAs (the right panel). (d) HS-SY-II cell proliferation assay of the response to Fe(salen) release under external heating, showing outstanding thermo-stability. (e) HS-SY-II cytotoxicity assay of the BSA-CSNAs versus Fe(salen) as a function of concentration. (f) Release profiles of Fe(salen) from a BSA-CSNA suspension in the pH-dependent AMF-heating mode.