Figure 7
Microscopic imaging of human glioblastoma (U87) cells to evaluate the magneto-hyperthermal drug release efficacy of the bovine serum albumin (BSA)-CSNAs in response to dual stimuli (alternating magnetic field (AMF) and pH). The AMF-hyperthermal anticancer treatment was performed at pH 7.0 (a) and pH 6.0 (b). When exposed to AMF for 30 min, the cells at pH 6.0 were mostly dead, while they were partially viable at pH 7.4. A significant number of floating (dead) cells is shown in the bright field images (red arrows) after AMF-treatment for 30 min, which is not detectable in the fluorescence imaging. Scale bars=200 μm.
