Figure 10
From: A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration
Micro-CT analysis for the bone regeneration after implanting with MoS2-modified akermanite (MS-AKT) (a, b) and AKT (c, d) scaffolds in the critical-sized femoral defects of rabbits for 8 weeks. Red color stands for the formation of new bone (b, d). Histological analysis of MS-AKT (e, f) and AKT (g, h) scaffolds by Van Gieson staining after implanting for 8 weeks. (i) Quantitative analysis for new bone formation by Micro-CT analysis. (j) The heating curves of rabbits under near-infrared (NIR) irradiation (0.5 W cm−2, 10 min) to explore short-time photothermal treatment on long-term bone regeneration. Both MS-AKT and AKT scaffolds induced new bone formation around the scaffolds and in the macropores. There was no significant difference between two groups, indicating that in situ growth of MoS2 on AKT scaffolds had no obvious negative effect on formation of new bone and long-term bone regeneration was not affected by short-time NIR irradiation. MS-AKT scaffolds displayed excellent bone-forming ability in vivo.
