Abstract
Aim:
To evaluate whether estrogen receptor α (ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women.
Methods:
A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).
Results:
Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P > 0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01).
Conclusion:
We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women.
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References
Rees M . The age of menarche. ORGYN 1995; 4: 2–4.
Ito M, Yamada M, Hayashi K, Ohki M, Uetani M, Nakamura T . Relation of early menarche to high bone mineral density. Calcif Tissue Int 1995; 57: 11–4.
Treloar SA, Martin NG . Age at menarche as a fitness trait: nonadditive genetic variance detected in a large twin sample. Am J Hum Genet 1990; 47: 137–48.
Kaprio J, Rimpela A, Winter T, Viken RJ, Rimpela M, Rose RJ . Common genetic influences on BMI and age at menarche. Hum Biol 1995; 67: 739–53.
Chie WC, Liu YH, Chi J, Wu V, Chen A . Predictive factors for early menarche in Taiwan. J Formos Med Assoc 1997; 96: 446–50.
Jorm AF, Christensen H, Rodgers B, Jacomb PA, Easteal S . Association of adverse childhood experiences, age of menarche, and adult reproductive behavior: does the androgen receptor gene play a role? Am J Med Genet 2004; 125B: 105–11.
Gorai I, Tanaka K, Inada M, Morinaga H, Uchiyama Y, Kikuchi R, et al. Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. J Clin Endocrinol Metab 2003; 88: 799–803.
Kadlubar FF, Berkowitz GS, Delongchamp RR, Wang C, Green BL, Tang G, et al. The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiol Biomarkers Prev 2003; 12: 327–31.
Stoll BA . Western diet, early puberty, and breast cancer risk. Breast Cancer Res Treat 1998; 49: 187–93.
Pelletier G, El-Alfy M . Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 2000; 85: 4835–40.
Rosenfeld CS, Roberts RM, Lubahn DB . Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Mol Reprod Dev 2001; 59: 336–46.
Stavrou I, Zois C, Ioannidis JP, Tsatsoulis A . Association of polymorphisms of the oestrogen receptor alpha gene with the age of menarche. Hum Reprod 2002; 17: 1101–5.
Weel AE, Uitterlinden AG, Westendorp IC, Burger H, Schuit SC, Hofman A, et al. Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J Clin Endocrinol Metab 1999; 84: 3146–50.
Boot AM, van der Sluis IM, de Muinck Keizer-Schrama SM, van Meurs JB, Krenning EP, Pols HA, et al. Estrogen receptor alpha gene polymorphisms and bone mineral density in healthy children and young adults. Calcif Tissue Int 2004; 74: 495–500.
Walter MR . Newly identified actions of the vitamin D endocrine system. Endocr Rev 1992; 13: 719–64.
Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 1997; 16: 391–6.
Bretherton-Watt D, Given-Wilson R, Mansi JL, Thomas V, Carter N, Colston KW, et al. Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Br J Cancer 2001; 85: 171–5.
Uitterlinden AG, Fang Y, Van Meurs JB, Van Leeuwen H, Pols HA . Vitamin D receptor gene polymorphisms in relation to vitamin D related disease states. J Steroid Biochem Mol Biol 2004; 89–90: 187–93.
Qin YJ, Zhang ZL, Huang QR, He JM, Hu YQ, Zhao Q, et al. Association of vitamin D receptor and estrogen receptor-alpha gene polymorphism with peak bone mass and bone size in Chinese women. Acta Pharmacol Sin 2004; 25: 462–8.
Kitagawa I, Kitagawa Y, Kawase Y, Nagaya T, Tokudome S . Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism. Eur J Endocrinol 1998; 139: 522–7.
Qin YJ, Shen H, Huang QR, Zhao LJ, Zhou Q, Li MX, et al. Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. J Bone Miner Res 2003; 18: 1028–35.
Zhang YY, Long JR, Liu PY, Liu YJ, Shen H, Zhao LJ, et al. Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women. Biochem Biophys Res Commun 2003; 308: 777–83.
Anderson SE, Dallal GE, Must A . Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics 2003; 111: 844–50.
Wietzke JA, Welsh J . Phytoestrogen regulation of a vitamin D3 receptor promoter and 1, 25-dihydroxyvitamin D3 actions in human breast cancer cells. J Steroid Biochem Mol Biol 2003; 84: 149–57.
Willing M, Sowers M, Aron D, Clark MK, Burns T, Bunten C, et al. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res 1998; 13: 695–705.
Swami S, Krishnan AV, Feldman D . 1alpha, 25-Dihydroxyvitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cells. Clin Cancer Res 2000; 6: 3371–9.
Nyholt DR . Genetic case-control association studies: correcting for multiple testing. Hum Genet 2001; 109: 564–7.
Must A, Phillips SM, Naumova EN, Blum M, Harris S, Dawson-Hughes B, et al. Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember? Am J Epidemiol 2002; 155: 672–9.
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Xu, H., Long, Jr., Li, Mx. et al. Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women. Acta Pharmacol Sin 26, 860–864 (2005). https://doi.org/10.1111/j.1745-7254.2005.00122.x
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DOI: https://doi.org/10.1111/j.1745-7254.2005.00122.x
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