Abstract
Aim:
To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time.
Methods:
Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method.
Results:
The average diameter of the gelatin particle-PLGA microsphere composite was 5–18 μm, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation.
Conclusion:
A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.
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Li, Sh., Cai, Sx., Liu, B. et al. In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor. Acta Pharmacol Sin 27, 754–759 (2006). https://doi.org/10.1111/j.1745-7254.2006.00337.x
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DOI: https://doi.org/10.1111/j.1745-7254.2006.00337.x
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