Abstract
Calcium ions are the most ubiquitous and pluripotent cellular signaling molecules that control a wide variety of cellular processes. The calcium signaling system is represented by a relatively limited number of highly conserved transporters and channels, which execute Ca2+ movements across biological membranes and by many thousands of Ca2+-sensitive effectors. Molecular cascades, responsible for the generation of calcium signals, are tightly controlled by Ca2+ ions themselves and by genetic factors, which tune the expression of different Ca2+-handling molecules according to adaptational requirements. Ca2+ ions determine normal physiological reactions and the development of many pathological processes.
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Cheng, Hp., Wei, S., Wei, Lp. et al. Calcium signaling in physiology and pathophysiology. Acta Pharmacol Sin 27, 767–772 (2006). https://doi.org/10.1111/j.1745-7254.2006.00399.x
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DOI: https://doi.org/10.1111/j.1745-7254.2006.00399.x
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