Abstract
With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.
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Project supported in part by the Dan David Foundation and the Milman Fund for Pediatric Research. Dr Manov was supported by the Kamea Fund.
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Manov, I., Motanis, H., Frumin, I. et al. Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta Pharmacol Sin 27, 259–272 (2006). https://doi.org/10.1111/j.1745-7254.2006.00278.x
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DOI: https://doi.org/10.1111/j.1745-7254.2006.00278.x
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