Abstract
Aim:
To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence.
Methods:
Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months).
Results:
Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009).
Conclusion:
The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.
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Project supported by Chang Gung Memorial Hospital (Grant No CMRPD1003-III, CMRPD32015, and CMRPG331193) and the National Science Council of Taiwan, China (Grant No NSC94-2745-B-182-001-URD, NSC94-2320-B-182-009, and NSC 96-2314-B-182A-016-MY2).
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Tsui, Kh., Juang, Hh., Lee, Th. et al. Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Acta Pharmacol Sin 29, 364–370 (2008). https://doi.org/10.1111/j.1745-7254.2008.00747.x
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DOI: https://doi.org/10.1111/j.1745-7254.2008.00747.x
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