Abstract
The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.
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Acknowledgements
We thank members of the Li laboratory for valuable discussions, reviewers for helpful comments, and Alison Neal for editorial assistance. This work is supported by grants to ML from the National Institutes of Health (GM078579, MH084691) and Maryland Stem Cell Research Foundation (2010-MSCRFE-0164-00).
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Sun, H., Li, M. Antibody therapeutics targeting ion channels: are we there yet?. Acta Pharmacol Sin 34, 199–204 (2013). https://doi.org/10.1038/aps.2012.202
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DOI: https://doi.org/10.1038/aps.2012.202
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