Abstract
Aim:
To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
Methods:
This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively.
Results:
Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).
Conclusion:
Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.
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Acknowledgements
This study was supported by the National Natural Science Foundation of China (81070692, 81000360, and 81170803), the Program of the Shanghai Subject Chief Scientist (08XD1403000) and Science and Technology Commission of Shanghai Municipality (10DZ1950100), Academic Leaders in Health Sciences in Shanghai (XBR2011014) and Shanghai Leading Talent Plan (051).
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Tao, Mf., Zhang, Z., Ke, Yh. et al. Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population. Acta Pharmacol Sin 34, 1070–1074 (2013). https://doi.org/10.1038/aps.2013.13
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DOI: https://doi.org/10.1038/aps.2013.13
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