Abstract
Aim:
Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and a shifted balance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is involved in TAD pathogenesis. The aim of this study was to evaluate the association of 4 single-nucleotide polymorphisms (SNPs) in MMP-9 and TIMP-3 genes with TAD risk in Chinese Han population.
Methods:
A total of 206 Chinese patients with TAD and 180 controls were included in this study. Four SNPs (rs3918249, rs2274756, rs9609643 and rs8136803) were genotyped using high-throughput MALDI-TOF mass spectrometry. Allele and genotype association analyses were conducted using PLINK.
Results:
All the 4 SNPs resulted in Hardy-Weinberg equilibrium in patients and controls. The G allele frequency for the MMP-9 SNP rs2274756 was significantly higher in female TAD patients than in female controls (P=0.0099). Moreover, after adjusting for traditional cardiovascular risk factors (sex, age, hypertension, dyslipidemia, diabetes and smoking habit), the rs2274756 polymorphism (odds ratio: 0.30; 95% confidence interval: 0.11 to 0.79, P=0.015) resulted in an independent susceptibility factor for TAD in females. No associations were found between the other SNPs and TAD.
Conclusion:
The results provide strong evidence for an association between MMP-9 SNP rs2274756 and female TAD risk in Chinese Han population.
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Acknowledgements
This study was supported by grants from the National Natural Science Foundation of China (81170283 and 81070251), the Beijing Natural Science Foundation (7112041), the Program for New Century Excellent Talents in University (NCET-11-0899), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1074) and the Scientific Research Common Program of Beijing Municipal Commission of Education (SQKM201210025017). The authors thank all the volunteers who participated in the study.
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Wang, Xl., Liu, O., Qin, Yw. et al. Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chinese Han population. Acta Pharmacol Sin 35, 351–355 (2014). https://doi.org/10.1038/aps.2013.179
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DOI: https://doi.org/10.1038/aps.2013.179
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