Table 1 The miRNAs involved in the regulation of MDR-1.
From: Friend or foe: the role of microRNA in chemotherapy resistance
Tumor category | miRNA | Mechanism | Reference |
|---|---|---|---|
Breast cancer | miR-21 | Actively regulates MDR-1 and IAPs | |
miR-137 | Targets Y-box binding protein-1 (YB-1) and suppresses MDR | ||
miR-200c | Targets MDR-1 | ||
miR-298, miR-1253 | Targets MDR-1 directly | ||
miR-451 | Targets MDR-1 | ||
Glioblastoma | miR-221 | Targets MMP-9 and suppresses MDR | |
Colon cancer | miR-145 | Targets MDR-1 directly | |
Ovarian cancer | Let-7 | Regulates IMP-1 mediated stabilization of MDR-1 | |
miR-27a | Targets HIPK2 and increases MDR-1 | ||
miR-27a, miR-451 | Activates MDR-1 indirectly | ||
miR-130a | Targets PTEN and activates MDR | ||
Liver cancer | miR-122 | Targets MDR-1 and MRP | |
Leukemia | miR-27a, miR-331-5p | Targets MDR-1 directly | |
miR-138 | Suppresses MDR-1 | ||
Prostate cancer | miR-148a | Targets MSK1 and suppresses MDR |
