Figure 3
The effects of TA3 on the accumulation of d8-TCA in freshly isolated rat hepatocytes and SCRHs. D8-TCA (1 μmol/L) uptake by rat hepatocytes at 15 min, 37 °C, co-incubated with TA3 (5, 10, 20, and 50 μmol/L) in Na+-added (A) and Na+-free (B) buffer. Troglitazone (10 μmol/L) was used as a positive control. SCRHs were incubated with d8-TCA (1 μmol/L) for 15 min after TA3 (1, 5, and 10 μmol/L) treatment for 2 h (C) and 24 h (D), and the concentration of d8-TCA was measured. The data are presented as the mean±SD (n=4). bP<0.05, cP<0.01 vs vehicle.
