Figure 2
From: The role of the orphan nuclear receptor COUP-TFII in tumorigenesis
A model of COUP-TFII's role in prostate malignancy. PTEN inactivation drives prostate tumour initiation and progression. However, it also induces TGF-β signalling, which serves as a tumour growth barrier to restrict tumours in a premalignant state. In a later stage, alternative oncogenic insults stimulate COUP-TFII expression, which sequesters SMAD4 and blocks TGF-β signalling. Thus, COUP-TFII plays a crucial role in inducing indolent prostate cancers to develop into metastatic-prone cancers.
