Abstract
The transient receptor potential (TRP) superfamily contains at least 28 homologs in mammalian. These proteins form TRP channels are permeable to monovalent and divalent cations and participate in a variety of physiological functions. Dysregulation of TRP channels is responsible for numerous diseases. This review provides a brief short overview of mammalian TRP channels with a focus on TRPC5 and its role in cancers. Dysregulation of TRPC5 interrupts Ca2+ homeostasis in cancer cells, which activates signaling pathways that are highly associated with cancer progression, especially cancer chemoresistance. Based on the important role of TRPC5, we also discuss the potential of TRPC5 as a target for therapeutic intervention. Either direct targeting of TRPC5 or indirect interruption of TRPC5-related signaling pathways may effectively overcome cancer chemoresistance.
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Acknowledgements
We thank Prof IC Bruce for critical reading of the manuscript. This work was supported by the China National Natural Science Foundation 81572940 and 91439131 to Xin MA; 31200126 to Dong-xu HE; the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province (BK20140004 to Xin MA); the Program for New Century Excellent Talents in University of The Ministry of Education of China (NCET-12-0880 to Xin MA); the National High Technology Research and Development Program (863 Program) of China (SQ2015AA020948 to Xin MA); and Fundamental Research Funds for the Central Universities (JUSRP51311A and JUSRP51519 to Xin MA and Jin JIAN).
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He, Dx., Ma, X. Transient receptor potential channel C5 in cancer chemoresistance. Acta Pharmacol Sin 37, 19–24 (2016). https://doi.org/10.1038/aps.2015.109
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DOI: https://doi.org/10.1038/aps.2015.109
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