Figure 4
Plasma concentrations of 3-O-methyltanshinol (M1; green curves/open circles), 4-O-methyltanshinol (M2; green curves/solid circles), tanshinol-3-O-sulfate (M7; brown curves), and unchanged tanshinol (blue curves) over time after an iv (2 mg/kg) and a po dose of tanshinol (10 mg/kg) in rats not treated with (A and B) or treated with oral entacapone at 30 mg/kg (C and D). Panels E and F show comparative plasma AUC0–∞ of M1 (green open bars), M2 (green solid bars), M7 (brown bars), and unchanged tanshinol (blue bars) in rats not treated with entacapone and rats treated with entacapone. BLQ, blow the lower limit of quantification. The data represent means and standard deviations (n=3). bP<0.05 compared with the rat group that was not treated with entacapone.
