Figure 6
A metabolism/transport map of clearance of tanshinol (TSL). It shows the chemical fate, appearance and disappearance of tanshinol and its metabolites 3-O-methyltanshinol (M1), 4-O-methyltanshinol (M2), and tanshinol-3-O-sulfate (M7) from the principal compartments, and associated drug metabolizing enzymes and drug transporters. COMT, catechol-O-methyltransferase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; SULT, sulfotransferase; PAPS, 3′-phosphoadenosine-5′-phosphosulphate; PAP, 3′-phosphoadenosine-5′-phosphate; OAT/Oat, organic anion transporter; tHcy, total homocysteine.
