Figure 11 | Acta Pharmacologica Sinica

Figure 11

From: LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

Figure 11

A proposed model illustrating the mechanism underlying the efficiency of LX2343 in the amelioration of cognitive impairment in AD. LX2343 rescued neuronal cells from apoptosis by maintaining the integrity of mitochondrial function and morphology, alleviating the OS and JNK/p38 pathway and regulating anti- and pro-apoptotic proteins. In addition, LX2343 also inhibited tau hyperphosphorylation by functioning as a non-ATP competitive inhibitor of GSK-3β.

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