Figure 7
LX2343 effectively improved memory impairment in ICV-STZ rats. (A–D) Behavioral test and quantitative analyses in ICV-STZ rats. (A) Representative tracing graphs of the training trials. (B) Escape latency during platform trials in the MWM (Two-way ANOVA with repeated measures over time: treatment, *P<0.05, **P<0.01 versus SV. ##P<0.01 versus V). (C) Representative tracing graphs of the probe trials. (D) Times of platform crossing in probe trials (one-way ANOVA, Dunnett's multiple comparison test, n=10. *P<0.05, **P<0.01 versus SV. #P<0.05 versus V). V: Rats treated with vehicle, SV: Rats injected with STZ and treated with vehicle, SL: Rats injected with STZ and treated with 7 mg·kg−1·d−1 LX2343, SH: Rats injected with STZ and treated with 21 mg·kg−1·d−1 LX2343. All values were presented as the mean±SEM (n=10 per group).
