Figure 9 | Acta Pharmacologica Sinica

Figure 9

From: Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12

Figure 9Figure 9

G3-C12 peptide enhances in vivo tumor accumulation and anticancer efficacy of KLA. (A) Real-time fluorescence imaging of PC-3 tumor-bearing mice after intravenous administration of Cy5.5, HPMA-KLA-Cy5.5 or G3-C12-HPMA-KLA-Cy5.5. (B) Quantization of fluorescence in tumors excised from PC-3 tumor-bearing mice two days after they received intravenous injection of HPMA-KLA-Cy5.5 and G3-C12-HPMA-KLA-Cy5.5. (C) Tumor growth, (D) tumor weight and (E) animal survival in a mouse model of PC-3 tumors following various treatments (n=6 per treatment).

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