Table 1 Characteristics of the synthesized HPMA copolymer conjugates containing different functional groups.

From: Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12

Polymer conjugates

G3-C12 (wt %)

KLA (wt %)

Cy5.5 (wt %)

FITC (wt %)

Mw (kDa)

PDI

Zeta potential (mV)

Size (nm)

PDI

G3-C12-HPMA

9.74

   

26.6

1.52

3.98±0.40

12.31±0.25

0.25

HPMA-KLA

 

19.15

  

30.0

1.72

2.89±0.57

12.01±0.35

0.26

G3-C12-HPMA-KLA

9.14

18.87

  

32.2

1.83

3.34±0.92

12.68±0.14

0.25

(s)-G3-C12-HPMA-KLA

10.32

18.93

  

33.7

1.59

2.21±0.23

14.21±0.31

0.30

G3-C12-HPMA-FITC

9.38

  

5.53

30.2

1.41

1.69±0.34

11.20±0.43

0.19

HPMA-KLA-FITC

 

18.58

 

5.99

25.4

1.26

2.95±0.24

10.23±0.27

0.29

G3-C12-HPMA-KLA-FITC

10.4

17.13

 

5.52

26.2

1.20

3.21±0.42

14.48±0.16

0.28

(s)-G3-C12-HPMA-KLA-FITC

10.73

20.12

 

5.93

31.3

1.69

1.45±0.26

15.26±0.31

0.25

HPMA-KLA-Cy5.5

 

19.24

2.53

 

28.8

1.57

2.51±0.36

13.21±0.40

0.24

G3-C12-HPMA-KLA-Cy5.5

10.9

18.24

2.49

 

26.5

1.64

3.43±0.15

13.92±0.37

0.31

  1. Abbreviations: Mw, weight-averaged molecular weight; PDI, polydispersity index; FITC, fluorescein isothiocyanate; Cy5.5, cyanine 5.5.
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