Figure 3
Chemical structures of (A) DOX prodrug (P-DOX) and (B) Cypate-conjugated P-cypate diblock copolymer. (C) Self-assembly of pH and NIR light dual-responsive P-DOX/P-cypate micelles. (D) Schematic illumination for combating DOX-resistant breast cancer with the pH and NIR light dual-responsive P-DOX/P-cypate micelles (a: Cellular uptake; b: Lysosome dissociation; c: Cytosol release). Adapted with permission from 5. Copyright (2015) John Wiley & Sons, Inc.
