Figure 5 | Blood Cancer Journal

Figure 5

From: Resistance of MLL–AFF1-positive acute lymphoblastic leukemia to tumor necrosis factor-alpha is mediated by S100A6 upregulation

Figure 5

Examination of S100A6 expression in MLL–AFF1 transgenic (Tg) mouse. (a) Histopathological findings from 14-month-old wild-type (WT) and MLL–AFF1 Tg mice (original magnification × 4). Comparison of their spleens shows infiltration of lymphoma cells and destruction of the normal organ structure in the MLL–AFF1 Tg mouse. (b)Western blotting analysis of lysate from spleen of WT or MLL–AFF1 Tg mice. Upregulation of S100A6 and inhibition of upregulation of the p53–caspase 8–caspase 3 pathway were also confirmed in this mouse model. Densitometry measurements were standardized by those of WT.

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