Figure 1

Illustrative example of selected TCR V-beta CDR3 spectratypes in a patient with partial response (PR)/complete response (CR) (left) and in a patient with non-response (right). The number represents the specific V-beta chain family, followed by the complexity score in parentheses. The inter-observer variability in spectratype complexity scoring was less than 5%, as determined by a blinded review of three individual cases by three different investigators.