Figure 5 | Blood Cancer Journal

Figure 5

From: Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice

Figure 5

Oral administration of 17-DMAG blocks aggressive infiltration of Lck-Tax Tg cells into multiple organs of SCID mice. Two million Lck-Tax Tg cells were injected intraperitoneally into SCID mice. 17-DMAG was administered orally 5 days per week, with 5 mg/kg body weight (e–h) or 15 mg/kg body weight (i–l) or untreated (a–d). Mice were sacrificed after 21 days incubation, and organs were processed for Giemsa (a, e, i) or hematoxylin and eosin (HE, b–d, f–h and j–l) staining. Microscopic observations were performed and photographed with indicated magnifications. Tg, transgenic.

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