Figure 6 | Blood Cancer Journal

Figure 6

From: Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model

Figure 6

Results of mouse experiments with L540cy-induced tumors. (a) Treatment schedule indicating i.v. injection of cells, protein injection and days of measurement. (b) Relative tumor size is shown at time points as indicated upon treatment with mutant GbR201K-Ki4(scFv) versus control GbR201K-H22(scFv). The difference between the curves was determined to be statistically significant with P<0.001 (***). (c) Confocal microscopy of Ki4(scFv)-SNAP-BG-Vista-Green-stained tissue sections of control-treated L540cy tumors. (d) Receptor depending targeting of L540cy with Ki4(scFv)-SNAP-BG-747 in vivo after 6 h. Protein was applied i.v. into L540cy-bearing mice. Measurement was taken with deep-red filter set ((730–950 nm) (i) background signal, (ii) image with fluorescence signal (yellow, Ki4(scFv)-SNAP-BG-747).

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