Table 1a Patients characteristics with or without KIR incompatibility in the GVH direction
Factor | ALL, n (%) | AML, n (%) | ||||
|---|---|---|---|---|---|---|
KIR compatible | KIR incompatible | P | KIR compatible | KIR incompatible | P | |
Number of patients | 227 | 59 | 288 | 69 | ||
Year of transplant | 0.621 | 0.639 | ||||
2001–2005 (%) | 49 (22) | 11 (19) | 44 (15) | 9 (13) | ||
2006– | 178 (78) | 48 (81) | 244 (85) | 60 (87) | ||
Median age (years) | 27 | 33 | 0.895 | 47 | 50 | 0.195 |
0–15 | 83 (37) | 16 (27) | 0.355 | 41 (14) | 9 (13) | 0.926 |
16–39 | 58 (26) | 19 (32) | 79 (27) | 18 (26) | ||
>40 | 86 (38) | 24 (41) | 168 (59) | 42 (61) | ||
Male | 108 (48) | 38 (64) | 0.021 | 145 (50) | 44 (64) | 0.045 |
Disease status | 0.741 | 0.077 | ||||
CR1 | 153 (68) | 43 (73) | 182 (63) | 37 (54) | ||
CR2 | 69 (30) | 15 (25) | 95 (33) | 25 (36) | ||
>CR2 | 4 (2) | 1 (2) | 9 (3) | 6 (9) | ||
TNC infused × 107/kg | 3.04 (1.61–24.77) | 2.81 (1.45–24.91) | 0.461 | 2.70 (1.46–38.70) | 2.60 (1.59–10.84) | 0.103 |
Conditioning | ||||||
RIC | 47 (21) | 11 (19) | 0.703 | 101 (35) | 28 (41) | 0.392 |
TBI | 187 (82) | 52 (86) | 0.457 | 237 (82) | 60 (87) | 0.38 |
ATG | 0 | 0 | 0 | 0 | ||
HLA allele matching | <0.001 | 0.013 | ||||
0 miss | 16 (7) | 1 (2) | 14 (5) | 0 | ||
1 miss | 25 (11) | 2 (3) | 19 (7) | 3 (4) | ||
2 miss | 37 (16) | 3 (5) | 36 (13) | 3 (4) | ||
3 miss | 75 (33) | 12 (20) | 92 (32) | 22 (32) | ||
4 miss | 46 (20) | 23 (39) | 73 (25) | 18 (26) | ||
>4 miss | 28 (12) | 18 (31) | 54 (19) | 23 (33) | ||
GVHD prophylaxis | 0.202 | 0.687 | ||||
CsA±MTX | 96 (42) | 31 (53) | 133 (46) | 30 (44) | ||
FK±MTX | 126 (56) | 28 (47) | 151 (53) | 38 (55) | ||
