Table 3a Multivariate analysis for each event KIR ligand incompatibility in the GVH direction with ALL patients

Variables	Reference	HR	95% CI		P-value
Overall survival
KIR incompatible	Compatible	0.87	0.53	1.40	0.557
Age >40	Age 0–15	4.25	2.31	7.83	<0.001
Male	Female	1.08	0.72	1.62	0.718
CR2–	CR1	2.09	1.39	3.16	<0.001
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.93	0.59	1.45	0.739
Disease-free survival
KIR incompatible	Compatible	0.79	0.49	1.29	0.352
Age >40	Age 0–15	2.41	1.39	4.18	0.002
Male	Female	1.00	0.68	1.47	0.995
CR2–	CR1	1.67	1.12	2.47	0.011
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.85	0.56	1.30	0.465
Relapse incidence
KIR incompatible	Compatible	0.95	0.43	2.10	0.91
Age >40	Age 0–15	0.59	0.26	1.32	0.2
Male	Female	0.65	0.39	1.10	0.11
CR2–	CR1	1.37	0.80	2.35	0.250
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.69	0.35	1.35	0.280
Non-relapse mortality
KIR incompatible	Compatible	0.71	0.37	1.39	0.32
Age >40	Age 0–15	6.96	2.93	16.57	<0.001
Male	Female	1.44	0.79	2.64	0.24
CR2–	CR1	1.62	0.90	2.92	0.100
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.13	0.61	2.10	0.700
Engraftment
KIR incompatible	Compatible	1.08	0.78	1.50	0.63
Age >40	Age 0–15	0.55	0.39	0.78	<0.001
Male	Female	0.77	0.58	1.02	0.066
CR2–	CR1	0.76	0.56	1.02	0.067
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.08	0.82	1.43	0.590
Infused cell >2.5 × 10⁷/kg	≦2.5	1.02	0.76	1.36	0.910
MAC	RIC	0.79	0.58	1.09	0.15
Acute GVHD
KIR-incompatible	Compatible	1.06	0.64	1.74	0.83
Age >40	Age 0–15	0.95	0.53	1.71	0.87
Male	Female	1.16	0.75	1.79	0.52
CR2–	CR1	1.34	0.89	2.02	0.170
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.40	0.86	2.28	0.180

Abbreviations: ALL, acute lymphoblastic leukemia; CI, confidence interval; CR, complete remission; GVH, graft-versus-host; GVHD, GVH disease; HLA, human leukocyte antigen; HR, hazard ratio; KIR, killer cell immunoglobulin-like receptor; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning.

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