Table 3b Multivariate analysis for each event KIR ligand incompatibility in the GVH direction with AML patients

Variables	Reference	HR	95% CI		P-value
Overall survival
KIR incompatible	Compatible	0.93	0.58	1.49	0.752
Age >40	Age 0–15	1.93	0.98	3.79	0.057
Male	Female	1.78	1.21	2.60	0.003
CR2–	CR1	0.76	0.52	1.11	0.160
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.08	0.71	1.65	0.725
Disease-free survival
KIR incompatible	Compatible	1.02	0.65	1.59	0.945
Age >40	Age 0–15	1.31	0.71	2.42	0.380
Male	Female	1.48	1.03	2.12	0.033
CR2–	CR1	0.77	0.54	1.10	0.152
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.01	0.68	1.50	0.959
Relapse incidence
KIR incompatible	Compatible	0.59	0.31	1.14	0.12
Age >40	Age 0–15	0.61	0.27	1.38	0.24
Male	Female	0.65	0.39	1.09	0.1
CR2–	CR1	1.39	0.82	2.34	0.220
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.71	0.36	1.38	0.310
Non-relapse mortality
KIR incompatible	Compatible	0.95	0.52	1.72	0.86
Age >40	Age 0–15	2.59	0.99	6.76	0.052
Male	Female	1.71	1.05	2.77	0.031
CR2–	CR1	0.85	0.54	1.36	0.510
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.08	0.63	1.84	0.780
Engraftment
KIR incompatible	Compatible	0.97	0.71	1.339	0.89
Age >40	Age 0–15	0.94	0.67	1.332	0.74
Male	Female	0.92	0.73	1.181	0.53
CR2–	CR1	1.00	0.79	1.287	0.96
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.97	0.75	1.27	0.840
Infused cell >2.5 × 10⁷/kg	≦2.5	1.36	1.06	1.776	0.018
MAC	RIC	0.68	0.52	0.904	0.007
Acute GVHD
KIR incompatible	Compatible	0.84	0.51	1.40	0.51
Age >40	Age 0–15	0.50	0.27	0.94	0.031
Male	Female	1.10	0.75	1.61	0.62
CR2–	CR1	0.98	0.66	1.44	0.900
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.58	0.98	2.54	0.058

Abbreviations: AML, acute myeloid leukemia; CI, confidence interval; CR, complete remission; GVH, graft-versus-host; GVHD, graft-versus-host disease; HLA, human leukocyte antigen; HR, hazard ratio; KIR, killer cell immunoglobulin-like receptor; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning.

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