Table 3c Multivariate analysis for each event KIR ligand incompatibility in the HVG direction with ALL patients

Variables	Reference	HR	95% CI		P-value
Overall survival
KIR incompatible	Compatible	0.84	0.54	1.33	0.457
Age >40	Age 0–15	4.33	2.35	7.97	<0.001
Male	Female	1.08	0.72	1.62	0.718
CR2–	CR1	2.11	1.40	3.18	<0.001
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.91	0.59	1.41	0.671
Disease-free survival
KIR incompatible	Compatible	0.76	0.49	1.18	0.225
Age >40	Age 0–15	2.49	1.44	4.32	0.001
Male	Female	1.00	0.68	1.47	0.999
CR2–	CR1	1.70	1.14	2.51	0.009
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.84	0.55	1.26	0.394
Relapse incidence
KIR incompatible	Compatible	1.12	0.55	2.28	0.76
Age >40	Age 0–15	0.67	0.29	1.55	0.35
Male	Female	1.09	0.62	1.91	0.76
CR2–	CR1	0.75	0.42	1.34	0.330
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	0.95	0.52	1.74	0.870
Non-relapse mortality
KIR incompatible	Compatible	1.06	0.59	1.89	0.85
Age >40	Age 0–15	6.87	2.87	16.42	<0.001
Male	Female	1.43	0.77	2.64	0.26
CR2–	CR1	1.62	0.90	2.90	0.110
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.08	0.58	2.00	0.800
Engraftment
KIR incompatible	Compatible	0.66	0.47	0.91	0.013
Age >40	Age 0–15	0.56	0.4	0.78	<0.001
Male	Female	0.78	0.59	1.02	0.065
CR2–	CR1	0.71	0.52	0.96	0.026
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.14	0.86	1.5	0.370
Infused cell >2.5 × 10⁷/kg	≦2.5	1.04	0.78	1.39	0.800
MAC	RIC	0.80	0.58	1.09	0.160
Acute GVHD
KIR incompatible	Compatible	1.08	0.67	1.76	0.75
Age >40	Age 0–15	0.95	0.52	1.71	0.85
Male	Female	1.16	0.75	1.79	0.49
CR2–	CR1	1.35	0.88	2.07	0.170
HLA mismatching (>5/6)	HLA mismatching (6/6, 5/6)	1.41	0.87	2.29	0.160

Abbreviations: ALL, acute lymphoblastic leukemia; CI, confidence interval; CR, complete remission; GVHD, graft-versus-host disease; HLA, human leukocyte antigen; HR, hazard ratio; HVG, host-versus-graft; KIR, killer cell immunoglobulin-like receptor; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning.

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