Figure 2
From: Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis
Effect of NS-018 on survival and peripheral blood counts in JAK2V617F BMT mice. (a) Kaplan–Meier plot of untransplanted control mice treated with vehicle (control) and JAK2V617F BMT mice treated with vehicle (vehicle) or 50 mg/kg NS-018 (NS-018) for 40 days. Statistical significance in survival between the vehicle and NS-018 groups was assessed by the log-rank test (*P<0.05, eight mice per group). (b) White blood cell (WBC), (c) neutrophil (NEUT) and lymphocyte (LYMPH), (d) red blood cell (RBC) and reticulocyte (RETIC) and (e) platelet (PLT) counts. Bars represent the mean±s.e.m. The statistical significance of differences between the control and vehicle groups (#P<0.05) and between the vehicle and NS-018 groups (*P<0.05) were assessed by the Welch test.
