Figure 3
From: Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis
Effect of NS-018 on spleen weight and bone marrow fibrosis in JAK2V617F BMT mice. NS-018 was orally administered for 40 days at 50 mg/kg twice a day. After treatment, spleens and femurs were removed. (a) Spleen weight. Bars represent the mean±s.e.m. The statistical significance of differences between the control and vehicle groups (##P<0.01) and between the vehicle and NS-018 groups (**P<0.01) was assessed by the Welch test. (b–d) Spleen sections stained with hematoxylin and eosin (original magnification × 40). (e–g) Bone marrow tissue sections prepared from femur and stained for reticulin (original magnification × 200).
