Table 1 Advantages and disadvantages of iPS cells vs other types of pluripotent stem cells (see text for references)

From: Induced pluripotent stem cells in hematology: current and future applications

 

Pluripotency

Preservation of sex-specific gene imprinting

Tissue-specific epigenetic memory

Strength of selection → clonal variability of nuclear reprogramming

Genetic (CNV)/ epigenetic errors

Derivation frequency

ES

++++

++++

+

++++

+

++++

ntES

+++

 

++

++

+++

++

pES

++

Female only

+++

++

++

+++

ahES

++

Male only

+++

++

++

+++

iPS

++

+

++++

+

++++

+/++++

  1. Abbreviations: +, low; ++, moderate; +++, high; ++++, very high; ahES, androgenetic haploid ES cells; CNV, copy number variation; ES cell, embryonic stem cell; iPS cell, induced pluripotent stem cell; nt, nuclear transfer ES cells; pES, parthenogenetic ES cells.
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