Figure 4
From: Role of Bruton’s tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells
BTK inhibition results in a higher proportion of cells in the G2+M cell cycle phase and proliferation in MM cells within the BM microenvironment. (a) INA6 MM cells infected with BTK-KD or scrambled control (CONT) shRNA were extracted after 10 weeks from implanted bones of SCID-rab mice; cell cycle was analyzed with flow cytometry. (b) BTK-KD and CONT cells were extracted from implanted bones of SCID-rab mice 5 and 7 weeks after engraftment; BrdU incorporation was analyzed with flow cytometry.
