Figure 1 | Blood Cancer Journal

Figure 1

From: Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma

Figure 1

CG-rich region at the 5′ end of the PRDM1 gene. (a) The 5′ region of the PRDM1 gene is predicted to contain a CG island spanning the promoter region and exon 1. The genomic region analyzed by bisulfite sequencing (−325 to +224) is indicated. The filled region indicates the open reading frame; the bent arrow denotes the transcription start site. (b) The sequence at the 5′ end of PRDM1, including the region −325 to +224 analyzed by bisulfite sequencing, is depicted. The three portions of sequence that were separately analyzed in formalin-fixed, paraffin-embedded primary BLs are highlighted in gray. The 41 CpG dinucleotides interrogated are numbered within the sequence. The boundaries of the predicted CpG island are indicated by horizontal arrows.

Back to article page