Figure 2 | Blood Cancer Journal

Figure 2

From: Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma

Figure 2

EBV-positive BL cell lines and primary tumors are frequently methylated in the PRDM1 gene. (a) Bisulfite sequencing of the PRDM1 gene was performed on eight EBV-positive BL cell lines, two EBV-negative BL cell lines, five LCL and six normal B-cell subets (two naive, two memory and two GC B cells). PRDM1 hypermethyation was observed exclusively in EBV-positive cell lines analyzed. (b) The distribution and PRDM1 methylation status of the analyzed BL cases are illustrated by pie charts. A total of 44 BLs or BL-related lymphomas were analyzed, of which 23 were EBV-positive and 21 were EBV-negative. They were comprised of 30 non-HIV BL, 9 HIV-related BL and 5 BCL, U. PRDM1 hypermethylation was seen in 12 of 23 EBV-positive BL/BCL, U, but none of the 21 EBV-negative BL/BCL, U cases (P<0.05).

Back to article page