Figure 3 | Blood Cancer Journal

Figure 3

From: Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma

Figure 3

Methylation analysis of PRDM1 in BL cell lines and primary tumors. The percentage of methylation determined by bisulfite cloning and sequencing at each of the 41 CpG dinucleotides from −325 and +224 is summarized for all BL cell lines and primary cases, as well as for LCLs and normal B-cell subsets. BL cell lines and primary cases demonstrating PRDM1 hypermethylation, all of which were EBV-positive, are highlighted in gray. Significant hypermethylation was not observed in EBV-positive LCLs, normal B cells or EBV-negative BL cell lines or primary cases. Cases E3 and F1 were diagnosed as BCL, U, with features intermediate between BL and DLBCL (BCL, U). The remaining primary cases were BLs.

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