Figure 1

(a) Schematic outline of the study. Four patient groups were analyzed. FLnonHT: patients diagnosed with FL and followed at least 11 years with no transformation to DLBCL (n=5); FLHT: patients diagnosed with FL with subsequent transformation to DLBCL at a time point from 1 to 10 years after first diagnosis with FL (n=7); secondary DLBCL: patients diagnosed with DLBCL following a previously known FL diagnosis (n=6); and de novo DLBCL: patients diagnosed with DLBCL with no evidence of previous FL (n=9). Protein expression profiles were compared between FLnonHT and FLHT (analysis A), between FLHT and secondary DLBCL (analysis B), and between secondary and de novo DLBCL (analysis C). (b) 2D PAGE analyses. Representative gels are shown from each group. Spots identified as differentially expressed are shown on the representative gels in the specified analyses. Analysis A: protein profiles compared between FLnonHT and FLHT (6 spots); analysis B: between FLHT and secondary DLBCL (9 spots); and analysis C: a comparison between secondary and de novo DLBCL (28 spots).