Table 4 Impact of dexamethasone addition on toxicity profile
From: Phase 2 trial of ixazomib in patients with relapsed multiple myeloma not refractory to bortezomib
Ixazomib alone (N=163 cycles) | Ixazomib+dexamethasone (N=173 cycles) | P-value (Fisher’s exact) | |
|---|---|---|---|
Grade 3+ heme | 30 (18%) | 7 (4%) | <0.001 |
Grade 3+ non-heme | 15 (9%) | 7 (4%) | 0.08 |
Grade 3+ GI | 7 (4%) | 1 (0.6%) | 0.03 |
All grade GI | 124 (76%) | 84 (49%) | <0.001 |
