Figure 1

MARCKS expression and localization in MCL and CLL. (a) List of six genes significantly deregulated in both diagnoses in opposite directions. Fold change (FC) to normal controls. (b) Localization of MARCKS in peripheral blood mononuclear cells (PBMC) of MCL and CLL patients from the validation group and healthy controls. Cells were fixed and fluorescently labeled for MARCKS. DAPI was used for nuclear staining. Scale bars represent 5 μm. (c) Fluorescence intensity of the anti-MARCKS antibody in the cytoplasm, nucleus and its ratio determined by IF in PBMC of MCL and CLL patients from the validation group. Results of Student’s t-test are displayed. **P⩽0.01, ****P⩽0.0001.