Table 2 Values of serum bone metabolism parameters and activin-A in all study groups

From: High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma

 

CTX (ng/ml)

bALP (U/l)

Activin-A

NDMM (N=105)

0.75±0.31 (0.517)

12.1±1.8 (11.6)

1228±789 (555)

Healthy controls (N=30)

0.24±0.23 (0.180)

14.3±9.6 (13.1)

355±112 (321)

SMM (N=33)

0.47±1.05 (0.253)

15.8±9.2 (14.7)

412±223 (347)

MGUS (N=23)

0.37±0.17 (0.296)

19.2±11.3 (17.9)

471± 332 (351)

P-value (NDMM vs controls)

<0.001

0.045

<0.001

P-value (NDMM vs SMM)

0.009

0.032

<0.001

P-value (NDMM vs MGUS)

0.007

0.018

0.008

P-value (SMM vs controls)

0.178

0.187

0.678

P-value (SMM vs MGUS)

0.564

0.026

0.876

P-value (MGUS vs controls)

0.106

0.012

0.690

  1. Abbreviations: bALP, bone-specific alkaline phosphatase; CTX, C-telopeptide of collagen type-I; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; NDMM, newly diagnosed symptomatic MM; SMM, smoldering MM.
  2. Mean±s.d. (median).
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