Table 2 Association of gene alterations with overall survival (Cox regression)

From: Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic marker

 

Gene

HR

95% CI (lower)

95% CI (higher)

Adjusted P-value

Univariate

TP53 a

2.48

1.77

3.49

<0.001

 

CDKN2C b

3.66

2.33

5.76

<0.001

 

RB1 a , b

4.07

2.63

6.29

<0.001

 

WHSC1 c

3.38

2.06

5.54

<0.001

 

FAF1 b

4.72

2.40

9.28

<0.001

 

t(4;14)d

2.23

1.48

3.36

<0.001

Multivariate

TP53 a

2.30

1.634

3.252

<0.001

 

CDKN2C b

1.30

2.317

5.799

<0.001

 

RB1 a , b

1.34

2.45

5.979

<0.001

 

WHSC1 c

1.13

1.874

5.091

<0.001

  1. Abbbreviations: CI, confidence interval; GEP, gene expression profiling; HR, hazard ratio.
  2. aBase substitutions.
  3. bLoss.
  4. cRearrangements.
  5. dPredicted by GEP.
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