Table 2 Treatment of Gata1low mice with ruxolitinib decreases splenomegaly but has modest effects on blood values and bone marrow cellularity

From: The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature

Mouse

Spleen

Cells/femur (× 106)

 

Weight (mg)

Length (cm)

Cells (× 106)

 

V (n=6)

343.3±86.9

2.6±0.2

237.9±79.7

8.6±1.9

T (n=6)

231.7±43.1a

2.5±0.3

145.7±66.8a

11.5±9.4

WT (n=12)

100.0±10.0

NA

159.0±22

16.2±1.8

Gata1low(n=12)

430.0±45.0

3.1

393.0±38.0

9.7±0.7

  1. Abbreviations: NA, not available; T, treatment; V, vehicle; WT, wild type.
  2. aValue statistically different (P<0.05) from those observed in wild-type mice.
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