Figure 3
From: Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies
In vivo activity of IgG1 and IgG2σ anti-CD47 mAbs in AML xenograft models. (a) Ten million HL60 cells were implanted into NSG mice (n=5/group) on day 0 and mice received twice weekly treatments for 3 weeks (10 mg/kg) starting day 6 after implant (final day 23; grey-shaded area). Control mice were killed on day 27. (b) Ten million Kasumi-3 cells were implanted into NSG mice (n=5/group) on day 0 and mice received twice weekly treatments (10 mg/kg) for 6 weeks, starting day 6 after implant (final day 44; grey-shaded area). (c) Five million MV4-11 cells were implanted into NSG mice (n=5/group) on day 0 and mice received twice weekly treatments (10 mg/kg) for 3 weeks, starting day 6 after implant (final day 23; grey-shaded area). Control mice were killed on day 34. (a–c) The graphs show peripheral blood leukemic burden (human CD45+ cells) over time, which was monitored weekly, starting on day 14 (HL60 and Kasumi-3) or day 21 (MV4-11).
