Abstract
Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Adam, M., Thorburn, M., Gibbs, W. et al. Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia. Br J Cancer 24, 266–276 (1970). https://doi.org/10.1038/bjc.1970.30
Issue date:
DOI: https://doi.org/10.1038/bjc.1970.30
