Abstract
A new series of LH-RH analogues containing an Azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH and FSH were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice daily), but plasma oestradiol concentrations were reduced to those in ovariectomized rats. The weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treatment regime, producing the effects of chemical castration.
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Maynard, P., Nicholson, R. Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats. Br J Cancer 39, 274–279 (1979). https://doi.org/10.1038/bjc.1979.51
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DOI: https://doi.org/10.1038/bjc.1979.51
