Abstract
The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.
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Hietanen, P., Blomqvist, C., Wasenius, VM. et al. Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?. Br J Cancer 71, 1029–1032 (1995). https://doi.org/10.1038/bjc.1995.198
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DOI: https://doi.org/10.1038/bjc.1995.198
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