Table 1 Common susceptibility variants for prostate and breast cancer identified through GWAS

From: Polygenic susceptibility to prostate and breast cancer: implications for personalised screening

dbSNP No.	Locus/gene	Risk-allele frequency	Odds ratio per allele	Variance	Reference
Prostate
rs12621278	2q31/ITGA6	0.94	1.30	0.008	Eeles et al (2009)
rs721048	2p15	0.19	1.15	0.002	Gudmundsson et al (2008)
rs1465618	2p21/THADA	0.23	1.08	0.002	Eeles et al (2009)
rs2660753	3p12	0.11	1.18	0.002	Eeles et al (2008)
rs10934853	3q21.3	0.28	1.12	0.002	Gudmundsson et al (2009)
rs7679673	4q24 /TET2	0.55	1.09	0.004	Eeles et al (2009)
rs17021918	4q22/PDLIM5	0.66	1.10	0.003	Eeles et al (2009)
rs12500426	4q22/PDLIM6	0.46	1.08	0.007	Eeles et al (2009)
rs9364554	6q25	0.29	1.17	0.013	Eeles et al (2008)
rs6465657	7q21	0.46	1.12	0.007	Eeles et al (2008)
rs10486567	7p15 /JAZF1	0.77	1.12	0.009	Thomas et al (2008)
rs2928679	8p21	0.42	1.05	0.010	Eeles et al (2009)
rs1512268	NKX3.1	0.45	1.18	0.014	Eeles et al (2009)
rs620861	8q24	0.61	1.28	0.024	Al Olama et al (2009)
rs10086908	8q24	0.70	1.25	0.007	Al Olama et al (2009)
rs445114	8q24	0.64	1.14	0.041	Gudmundsson et al (2009)
rs16902094	8q24	0.15	1.21	0.015	Gudmundsson et al (2009)
rs6983267	8q24	0.50	1.26	0.010	Yeager et al (2007)
rs1447295	8q24	0.10	1.62	0.004	Amundadottir et al (2006)
rs16901979	8q24	0.03	2.10	0.002	Gudmundsson et al (2007a)
rs4962416	10q26 /CTBP2	0.27	1.17	0.013	Thomas et al (2008)
rs10993994	10q11/MSMB	0.24	1.25	0.014	Eeles et al (2008), Thomas et al (2008)
rs7127900	11p15	0.20	1.22	0.011	Eeles et al (2009)
rs7931342	11q13	0.51	1.16	0.012	Eeles et al (2008), Thomas et al (2008)
rs4430796	17q12 /HNF1B	0.49	1.24	0.015	Gudmundsson et al (2007b)
rs11649743	HNF1B	0.80	1.28	0.015	Sun et al (2008)
rs1859962	17q24.3	0.46	1.24	0.017	Gudmundsson et al (2007b)
rs2735839	19q13/KLK2,KLK3	0.85	1.20	0.001	Eeles et al (2008)
rs8102476	19q13.2	0.54	1.12	0.011	Gudmundsson et al (2009)
rs5759167	22q13	0.53	1.16	0.015	Eeles et al (2009)
rs5945619	Xp11	0.28	1.12	0.002	Eeles et al (2008), Gudmundsson et al (2008)
Breast
rs11249433	1p11.2	0.39	1.16	0.010	Thomas et al (2009)
rs1045485	2q33 /CASP8	0.85	1.14	0.004	Cox et al (2007)
rs13387042	2q35	0.49	1.12	0.006	Milne et al (2009)
rs4973768	3p24 /NEK10, SLC4A7	0.46	1.11	0.005	Ahmed et al (2009)
rs889312	5q11/MAP3K1	0.28	1.13	0.006	Easton et al (2007)
rs4415084	5p12/MRPS30	0.40	1.19	0.015	Stacey et al (2008)
rs2046210	6p12/ESR1	0.36	1.29	0.030	Zheng et al (2009)
rs13281615	8q24	0.40	1.08	0.003	Easton et al (2007)
rs1011970	9	0.17	1.09	0.002	Turnbull et al (2010)
rs2981582	10q26/FGFR2	0.38	1.26	0.025	Udler et al (2009)
rs2380205	10p15	0.43	0.94	0.002	Turnbull et al (2010)
rs10995190	10q21/ZNF365	0.85	1.16	0.006	Turnbull et al (2010)
rs704010	10q22	0.39	1.07	0.002	Turnbull et al (2010)
rs614367	11q13	0.15	1.15	0.005	Turnbull et al (2010)
rs3817198	11p15/LSP1	0.30	1.07	0.002	Easton et al (2007)
rs999737	14q24/RAD51L1	0.76	1.06	0.001	Thomas et al (2009)
rs1244362	16q12/TOX3	0.25	1.20	0.014	Easton et al (2007), Stacey et al (2007)
rs6504950	17q/COX11	0.73	1.05	0.001	Ahmed et al (2009)

Abbreviations: dbSNP=Single Nucleotide Polymorphism database; GWAS=genome-wide association study. Reported risk allele frequency in Europeans.

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Table 1 Common susceptibility variants for prostate and breast cancer identified through GWAS

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