Table 3 Univariate and multivariate analyses/logistic regression for acute neurological toxicities (n=2610)

From: Early toxicity predicts long-term survival in high-grade glioma

  

Univariate analysis

Multivariate analysis b

Variable

Comparison

OR (95% CI) a

P -value

OR (95% CI) a

P -value

Age

<50

—

   
 

⩾50

1.59 (1.1, 2.2)

0.008

—

—

Zubrod

0

—

   
 

1, 2, 3

2.72 (1.9, 3.8)

<0.0001

1.77 (1.1, 2.7)

0.010

Surgery

Partial/total resection

—

 

—

 
 

Biopsy

1.63 (1.2, 2.2)

0.0029

1.43 (1.0, 2.0)

0.038

Neurological dysfunction

None/minor

—

 

—

 
 

Moderate/severe

2.91 (2.1, 4.0)

<0.0001

1.80 (1.2, 2.7)

0.0054

Mental status

Normal function

—

 

—

 
 

Minor/gross confusion

2.48 (1.8, 3.4)

<0.0001

1.69 (1.2, 2.4)

0.0025

Twice-daily RT

No

—

 

—

 
 

Yes

1.79 (1.32, 2.43)

0.0002

1.67 (1.2, 2.3)

0.0025

Histology

AA

—

   
 

GBM

0.95 (0.6, 1.6)

0.84

—

—

Chemotherapy

No

—

   
 

Yes

0.79 (0.5, 1.2)

0.22

—

—

Biological-equivalent dose

⩽120

—

   
 

>120

0.84 (0.5, 1.4)

0.52

—

—

  1. Abbreviations: AA=anaplastic astrocytoma; BED=biological-equivalent dose; CI=confidence interval; GBM=glioblastoma; OR=odds ratio; RT=radiation therapy.
  2. aOdds ratio: the odds ratio of 1 indicates no difference between the two subgroups.
  3. bMultivariate model derived from stepwise selection.
  4. Variable(s) not included in final model: age (dropped out during the stepwise selection process).
  5. Variable(s) dropped from modelling as not significant with reference variables: histology, chemotherapy, BED (not significant during the univariate setting).
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