Table 5 Univariate and multivariate analysis/cox proportional hazards model for overall survival

From: Early toxicity predicts long-term survival in high-grade glioma

Variable

Comparison

HR (95% CI)

P -value

HR (95% CI)

P -value

RPA

I, II

—

   
 

III

3.24 (2.6, 4.1)

<0.0001

3.27 (2.6, 4.1)

<0.0001

 

IV

5.41 (4.4, 6.7)

<0.0001

5.41 (4.4, 6.7)

<0.0001

 

V, VI

10.10 (8.1, 12.6)

<0.0001

9.92 (7.9, 12.4)

<0.0001

Twice-daily RT

No

—

   
 

Yes

0.93 (0.9, 1.0)

0.09

  

Chemotherapy

No

—

   
 

Yes

0.78 (0.7, 0.9)

<0.0001

  

BED

⩽120

—

   
 

>120

0.99 (0.9, 1.1)

0.86

  

Acute CNS

No

—

   
 

Yes

1.77 (1.5, 2.1)

<0.0001

1.43 (1.2, 1.7)

<0.0001

  1. Abbreviations: BED=biological-equivalent dose; CI=confidence interval; CNS=central nervous system; HR=hazards ratio; RPA=recursive partitioning analysis; RT=radiation therapy.
  2. Multivariate model derived from stepwise selection.
  3. Variable(s) not included in final model: twice-daily RT and chemotherapy (dropped out during the stepwise selection process).
  4. Variable dropped from modelling as not significant with reference variables: BED (not significant during the univariate setting).
Back to article page